Sulfonylureas were discovered in 1942, and several have been available since the 1960s. Glyburide is a second-generation sulfonylurea, it works by increasing plasma insulin concentrations.
WHY THE RISK OF HYPOGLYCEMIA?
The biological effect of sulfonylureas often lasts much longer than their plasma half-life, because of receptor interaction and formation of active metabolites, persisting 24 h or more. Moreover, their half-life is prolonged in the presence of renal failure.
REFERENCES
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Although rare, the differential diagnosis of hypoventilation and hypercapnia respiratory failure includes hypothyroidism. It is…
B-type natriuretic peptide (BNP) is a hormone created in response to cardiac wall stretch due…
A common finding described on computed tomography (CT) imaging. A disease with a peribronchovascular distribution…
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