Dementia with Lewy bodies (DLB) is the second most common cause of neurodegenerative dementia in the elderly (accounting for 15-20% on autopsy- => alpha-synuclein deposition).
It is characterized as clinically:
WHY AVOID HALDOL? Individuals suffering from DLB have a reduction in post-synaptic dopaminergic (D2) receptor activity. Hence when given D2-receptor antagonists, particularly traditional neuroleptic agents (i.e haldol), it can provoke severe neuroleptic sensitivity reactions (catatonia, decreased LoC, muscle rigidity) in up to 50% of DLB patients.
NOTE: consider new generation anti-psychotics (Quetiapine is preferred by some LBD experts).
The two drugs are not interchangeable nor dose equivalents. Mycophenolate mofetil is a semi synthetic…
Two systematic reviews have assessed the diagnostic accuracy of elements of the medical history, physical…