Signs of intravascular hemolysis include:
- Elevated lactate dehydrogenase (marker of tissue damage)
- Reduction in haptoglobin (binds free hemoglobin [Hb])
- UNnconjugated hyperbilirubinemia (byproduct of hemolysis)
*Be certain to check for increased reticulocytes ( bone marrow compensatory response) and blood smear (i.e Spherocytes, Schistocytes, Sickle cells)
- W. Barcellini and B. Fattizzo, “Clinical Applications of Hemolytic Markers in the Differential Diagnosis and Management of Hemolytic Anemia,” Disease Markers, vol. 2015, Article ID 635670, 7 pages, 2015. doi:10.1155/2015/635670
- Kato GJ, McGowan V, Machado RF, et al. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood. 2006;107(6):2279-2285. doi:10.1182/blood-2005-06-2373.