Carcinoid tumors are rare neuroendocrine tumors which originate most often in the bowel, less commonly in the lungs, and rarely in the reproductive tract.
Carcinoid syndrome will occur in a small percentage of patients (~10%).
Symptoms include:
Facial flushing
Abdominal cramps and diarrhea
Bronchospasm
MECHANISM: Tumor-derived 5-HTP metabolites, such as serotonin, akinins, and prostaglandins entering systemic circulation cause these symptoms.
Carcinoid syndrome is usually seen in patients with lung primaries or liver metastases from bowel primary carcinoid tumour that escape the enterohepatic circulation and enter directly into the systemic blood supply.
Otherwise, if the mediators are released from a primary bowel carcinoid tumour, they are released into portal venous blood supply and are metabolized by the liver.
REFERENCES
The two drugs are not interchangeable nor dose equivalents. Mycophenolate mofetil is a semi synthetic…
Serum Creatinine can be a deceptive surrogate during an acute kidney injury. It may lag…
Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic diseases (i.e SLE, Juvenile idiopathic…
After creation of a percutaneous tracheotomy site for prolonged ventilation, one of the immediate complications…
Two systematic reviews have assessed the diagnostic accuracy of elements of the medical history, physical…
SYMPTOMS THAT RULE OUT (Lowest -LR): The absence of pain of sudden onset substantively decreases…
This website uses cookies.