Distinguishing between the coagulation abnormalities of liver disease vs. Disseminated intravascular coagulation (DIC) can be difficult as clinical and biochemical findings are similar.
However, Factor VIII levels are usually increased or normal in liver disease.
Whereas, Factor VIII levels are decreased in DIC.
WHY? Factor VIII is produced in endothelial cells rather than the liver; hence it is not affected by the process of cirrhosis.
REFERENCES
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