Factor VIII: DIC vs Liver Disease (Cirrhosis)

Distinguishing between the coagulation abnormalities of liver disease vs. Disseminated intravascular coagulation (DIC) can be difficult as clinical and biochemical findings are similar.

However, Factor VIII levels are usually increased or normal in liver disease. 

Whereas, Factor VIII levels are decreased in DIC.

WHY? Factor VIII is produced in endothelial cells rather than the liver; hence it is not affected by the process of cirrhosis.

REFERENCES

1. Senzolo M, Burra P, Cholongitas E, Burroughs AK. New insights into the coagulopathy of liver disease and liver transplantation. World J Gastroenterol. 2006;12(48):7725-36.
2. Mammen EF. Coagulation abnormalities in liver disease. Hematol Oncol Clin North Am. 1992 Dec;6(6):1247-57.