How does Allopurinol work?

Allopurinol => enzyme xanthine oxidase inhibitor

Therefore blocks the conversion of the purine metabolites (hypoxanthine and xanthine) into uric acid.

NOTE: Allopurinol is used to prevent gout attacks, not to treat them once they occur.

Indications for use:

  1. Recurrent gouty attacks (>3 within 1 year)
  2. Presentation of Gouty tophi
  3. Renal insufficiency or recurrent nephrolithiasis with hyperuricemia
  4. Tumour lysis syndrome

References

1. Pacher et. al. Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol. Pharmacol Rev. 2006 Mar; 58(1): 87–114.doi:  10.1124/pr.58.1.6

Get Medical Pearls directly to your inbox every week!
Weekly posts with high yield medical knowledge, directly to your mailbox!
Dr. C Humphreys

Internal Medicine

Recent Posts

Cause of Pericardial Effusion in Pulmonary Hypertension: Pathogenesis

It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…

1 week ago

Difference between Mycophenolate Mofetil vs. Mycophenolate Sodium

The two drugs are not interchangeable nor dose equivalents. Mycophenolate mofetil (Cellcept) is a semi…

3 weeks ago

What is an “Anephric” Creatinine Rise?

Serum Creatinine can be a deceptive surrogate during an acute kidney injury. It may lag…

10 months ago

Macrophage activation syndrome vs. Hemophagocytic lymphohistiocytosis

Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic diseases (i.e SLE, Juvenile idiopathic…

1 year ago

When does a Tracheostomy mature?

After creation of a percutaneous tracheotomy site for prolonged ventilation, one of the immediate complications…

1 year ago

JAMA: Does this patient have Heart Failure? Likelihood Ratios

Two systematic reviews have assessed the diagnostic accuracy of elements of the medical history, physical…

1 year ago

This website uses cookies.