Allopurinol => enzyme xanthine oxidase inhibitor
Therefore blocks the conversion of the purine metabolites (hypoxanthine and xanthine) into uric acid.
NOTE: Allopurinol is used to prevent gout attacks, not to treat them once they occur.
Indications for use:
- Recurrent gouty attacks (>3 within 1 year)
- Presentation of Gouty tophi
- Renal insufficiency or recurrent nephrolithiasis with hyperuricemia
- Tumour lysis syndrome
1. Pacher et. al. Therapeutic Effects of Xanthine Oxidase Inhibitors: Renaissance Half a Century after the Discovery of Allopurinol. Pharmacol Rev. 2006 Mar; 58(1): 87–114.doi: 10.1124/pr.58.1.6