Calcium homeostasis is normally under very tight control! There are 3 main sites of control: the gastrointestinal tract, bone, and kidney.
Hypercalcemia can happen for a variety of reasons (Multiple myeloma, cancer, Sarcoidosis, hyperparathyroidism, Milk-alkali syndrome, vitamin D intoxication etc.)
Subsequently acute renal failure may develop in the context of this pathology for several reasons.
HOW??
REFERENCES
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