Within the collecting duct of the kidney, Aquaporin water channels (AQP2) under the regulation of anti diuretic hormone (ADH) control the movement of water into principal cells.
Principal cells: Manage the Na+/K+ exchange in the collecting duct.
Long term lithium ingestion can manifest with polyuria/ polydipisa due to ADH resistance.
The proposed thought is principal cells uptake Lithium (cation) via the epithelial sodium channels (ENac) located on the luminal side of the principal cells.
The lithium accumulates in the principal cells, interfering with the ability of ADH to increase water permeability.
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