Within the collecting duct of the kidney, Aquaporin water channels (AQP2) under the regulation of anti diuretic hormone (ADH) control the movement of water into principal cells.
Principal cells: Manage the Na+/K+ exchange in the collecting duct.
Long term lithium ingestion can manifest with polyuria/ polydipisa due to ADH resistance.
HOW?
The proposed thought is principal cells uptake Lithium (cation) via the epithelial sodium channels (ENac) located on the luminal side of the principal cells.
The lithium accumulates in the principal cells, interfering with the ability of ADH to increase water permeability.
REFERENCES
Nocturia is a common symptom associated with obstructive sleep apnea. [1] Img Cred: Am J…
ASD (Atrial Septal Defect) Wide, Fixed split S2 (in contrast to the normal variation in…
Mixed apneas are characterized by absent respiratory effort and airflow in the first section of…
Although rare, the differential diagnosis of hypoventilation and hypercapnia respiratory failure includes hypothyroidism. It is…
B-type natriuretic peptide (BNP) is a hormone created in response to cardiac wall stretch due…
A common finding described on computed tomography (CT) imaging. A disease with a peribronchovascular distribution…
This website uses cookies.