Categories: Drugs/Metabolism

Nondihydropyridine vs. Dihydropyridine Calcium Channel Blockers

Dihydropyridine: Think Amlodipine and Nifedipine (-dipine)

They act through systemic vascular vasodilation of arteries. Can be used to treat angina. NOTE: can cause hypotension and cause reflex tachycardia (this is bad for patients with ischemic symptoms)

Non-Dihydropyridine: Think Verapamil and Diltiazem

They act selectively on the myocardium. This will reduce oxygen demand of myocardial tissue. They have minimal systemic effect and are less likely to cause reflex tachycardia.

REFERENCES

1. Hockerman, G.H.; Peterson, B.Z.; Johnson, B.D.; Catterall, W.A. (1997). “Molecular Determinants of Drug Binding and Action on L-Type Calcium Channels”. Annual Review of Pharmacology and Toxicology 37: 361–396

Get Medical Pearls directly to your inbox every week!
Weekly posts with high yield medical knowledge, directly to your mailbox!
Dr. C Humphreys

Internal Medicine

Share
Published by
Dr. C Humphreys

Recent Posts

What is Peribronchovascular Distribution on CT imaging?

A common finding described on computed tomography (CT) imaging. A disease with a peribronchovascular distribution…

3 months ago

Trapped Lung vs. Lung Entrapment

Though often used synonymously; Trapped Lung and Lung Entrapment technically describe separate entities along the…

10 months ago

Cause of Pericardial Effusion in Pulmonary Hypertension: Pathogenesis

It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…

11 months ago

Difference between Mycophenolate Mofetil vs. Mycophenolate Sodium

The two drugs are not interchangeable nor dose equivalents. Mycophenolate mofetil (Cellcept) is a semi…

11 months ago

What is an “Anephric” Creatinine Rise?

Serum Creatinine can be a deceptive surrogate during an acute kidney injury. It may lag…

2 years ago

Macrophage activation syndrome vs. Hemophagocytic lymphohistiocytosis

Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic diseases (i.e SLE, Juvenile idiopathic…

2 years ago

This website uses cookies.