Obstructive sleep apnea (OSA) is thought to lead to secondary polycythemia due to intermittent hypoxia, which stimulates the release of erythropoietin (EPO) and increases red blood cell production. While some studies suggest a connection between OSA and secondary polycythemia, the prevalence and significance of this relationship remain debated. A recent meta-anaylsis showed that only 2% of OSA patients had evidence of polycythemia [2].
References
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