HOW? Rifampin is a potent inducer of cytochrome P450 3A4 and accelerates the elimination of ethinyl estradiol and some progestin components, resulting in an increased risk of OCP failure
OTHER DRUGS TO AVOID: Griseofulvin (an antifungal), Phenytoin, St. John’s Wort and Chronic Alcohol use (can all induce CYP 3A4)
References
1. Barditch-Crovo P, Trapnell CB, Ette E et al (1999) The effects of rifampin and rifabutin on the pharmacokinetics and pharmacodynamics of a combination oral contraceptive. Clin Pharmacol Ther 65:428–438
2. Pelkonen, Olavi et al. Inhibition and induction of human cytochrome P450 enzymes: current status. Arch. Toxicol. October 2008, Volume 82, Issue 10, pp 667-715
Obstructive sleep apnea (OSA) is thought to lead to secondary polycythemia due to intermittent hypoxia,…
Catabolism of hemoglobin leads to the release of heme, which converts to biliverdin and then…
Tongue scalloping refers to the series of indentations along the sides of the tongue that…
Older age is recognized as a risk factor for obstructive sleep apnea.[1] But why? Suspected…
Being overweight (BMI ≥ 25 kg/m2)/Obese (BMI ≥ 30 kg/m2) is one of the most…
Nocturia is a common symptom associated with obstructive sleep apnea. [1] Img Cred: Am J…
This website uses cookies.