Psuedo Pelger-Huet cells have the morphological characterization of Neutrophils with hypolobation [hypo-segmented].
It can be a benign inherited defect (1/6000) of terminal Neutrophil differentiation due lamin B receptor gene mutations.
Or it can be seen in different pathological states like Myelodysplastic syndrome or CML, as well as with certain infections and drugs
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Wang E, Boswell E, Siddiqi I, Lu CM, Sebastian S, Rehder C, et al. Pseudo-pelger-huet anomaly induced by medications: a clinicopathologic study in comparison with myelodysplastic syndrome-related pseudo-pelger-huet anomaly. Am J Clin Pathol 2011;135:291–303.
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