Categories: Respirology/ ICU

What is Lactate?

WHAT IS IT? Lactate (conjugate base of Lactic acid) is formed from anaerobic metabolism of pyruvate by lactate dehydrogenase in the setting of insufficient oxygen. Lactate acts as a  serum marker for end organ perfusion. Increased Lactate= Increased ischemic damage to tissue (severity of shock). It is cleared by the liver and kidneys.

HOW?

  • As cells are starved of oxygen and substrate, they can no longer sustain aerobic oxygen production.
  • Eventually, cellular metabolism is no longer able to generate enough energy to power the components of cellular homeostasis, leading to disruption of cell-membrane Na/K+ ionic pumps.
  • Sodium moves into the cell making it hypertonic relative to the ECF. The cell swells, the cell membrane breaks down and cell death occurs.

REFERENCES

  1. Schwartz’s Principles of Surgery, 10e. Chapter 5: Shock. Brian S. Zuckerbraun; Andrew B. Peitzman; Timothy R. Billiar
Get Medical Pearls directly to your inbox every week!
Weekly posts with high yield medical knowledge, directly to your mailbox!
Dr. C Humphreys

Internal Medicine

Recent Posts

Mechanism of a Mixed Apnea

Mixed apneas are characterized by absent respiratory effort and airflow in the first section of…

2 months ago

How Does Hypothyroidism Cause Hypoventilation?

Although rare, the differential diagnosis of hypoventilation and hypercapnia respiratory failure includes hypothyroidism. It is…

2 months ago

Why is Pro-BNP/ BNP lower in Obesity?

B-type natriuretic peptide (BNP) is a hormone created in response to cardiac wall stretch due…

8 months ago

What is Peribronchovascular Distribution on CT imaging?

A common finding described on computed tomography (CT) imaging. A disease with a peribronchovascular distribution…

1 year ago

Trapped Lung vs. Lung Entrapment

Though often used synonymously; Trapped Lung and Lung Entrapment technically describe separate entities along the…

2 years ago

Cause of Pericardial Effusion in Pulmonary Hypertension: Pathogenesis

It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…

2 years ago

This website uses cookies.