non-steroidal anti-inflammatory drugs (NSAIDs) irritate gastroduodenal mucosa, suppress prostaglandin production, impair the ability of the mucosa to repair (reduction in gastric mucosa blood flood), inhibiting platelets function
HOW? Will block COX-2 to reduce inflammation [GOOD] but also block COX-1 [BAD]
Arachidonic Acid —> [COX] –> Prostaglandin
PGE2, remains a critical factor in gastric homeostasis. Prostaglandin E2 inhibits acid secretion through the EP3 receptor and the fluctuation of its levels as a result of NSAID therapy remains a major concern in preserving the integrity of the gastric mucosa
References
1. Wallace JL. How do NSAIDs cause ulcer disease? Baillieres Best Pract Res Clin Gastroenterol. 2000 Feb;14(1):147-59.
Mixed apneas are characterized by absent respiratory effort and airflow in the first section of…
Although rare, the differential diagnosis of hypoventilation and hypercapnia respiratory failure includes hypothyroidism. It is…
B-type natriuretic peptide (BNP) is a hormone created in response to cardiac wall stretch due…
A common finding described on computed tomography (CT) imaging. A disease with a peribronchovascular distribution…
Though often used synonymously; Trapped Lung and Lung Entrapment technically describe separate entities along the…
It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…
This website uses cookies.