Addison disease => autoimmune destruction of adrenal glands
The destruction results in less cortisol production by adrenals. This causes an increase in ACTH by the pituitary. ACTH is derived from pro-opiomelanocortin (POMC).
MECHANISM: POMC is also a precursor molecule for melanocyte stimulating hormone (MSH); hence increase melanocyte production.
REFERENCES
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