Categories: Gastrointestinal

Why does IgA Deficiency make Anti-TTG negative?

Current serological testing detects the IgA isotype of the Anti-TTG antibodies. Hence if a person is IgA deficient they will lack the prerequisite antibodies for testing despite the possibility of Celiac disease. The IgG class of anti-tTG may be ordered as an alternative in those who have a deficiency of IgA. Approximately 2-3% of the time in people with Celiac disease there is concurrent IgA deficiency and can lead to false-negative test results. [1]

References

1. Rittmeyer, C., Rhoads, J. M. 1996. IgA deficiency causes false-negative endomysial antibody results in celiac disease. J. Pediatr. Gastroenterol. Nutr. 23:504-506.

Get Medical Pearls directly to your inbox every week!
Weekly posts with high yield medical knowledge, directly to your mailbox!
Dr. C Humphreys

Internal Medicine

Recent Posts

Mechanism of a Mixed Apnea

Mixed apneas are characterized by absent respiratory effort and airflow in the first section of…

6 months ago

How Does Hypothyroidism Cause Hypoventilation?

Although rare, the differential diagnosis of hypoventilation and hypercapnia respiratory failure includes hypothyroidism. It is…

6 months ago

Why is Pro-BNP/ BNP lower in Obesity?

B-type natriuretic peptide (BNP) is a hormone created in response to cardiac wall stretch due…

1 year ago

What is Peribronchovascular Distribution on CT imaging?

A common finding described on computed tomography (CT) imaging. A disease with a peribronchovascular distribution…

2 years ago

Trapped Lung vs. Lung Entrapment

Though often used synonymously; Trapped Lung and Lung Entrapment technically describe separate entities along the…

2 years ago

Cause of Pericardial Effusion in Pulmonary Hypertension: Pathogenesis

It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…

2 years ago

This website uses cookies.