Neisseria meningitidis (Gram-negative cocci) life threatening cause of sepsis and bacterial meningitis.
Classically, individuals who lack terminal complement proteins (C5-C9) cannot form the membrane attack complex (MAC), which is needed for bacterial lysis of this encapsulated pathogen (can lead to a 1000- to 10,000-fold increased risk of meningococcal disease). More information here.
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