Infectious Diseases

C5-C9 Deficiency: Neisseria infections

Neisseria meningitidis (Gram-negative cocci) life threatening cause of sepsis and bacterial meningitis.

Classically, individuals who lack terminal complement proteins (C5-C9) cannot form the membrane attack complex (MAC), which is needed for bacterial lysis of this encapsulated pathogen (can lead to a 1000- to 10,000-fold increased risk of meningococcal disease). More information here.

REFERENCES

  1. Figueroa, J.E., and P. Densen. 1991. Infectious diseases associated with complement deficiencies. Clin. Microbiol. Rev. 4:359–395.
  2. Infectious diseases associated with complement deficiencies. Figueroa JE, Densen P. Clin Microbiol Rev. 1991 Jul; 4(3):359-95.
  3. Rosa D.D., Pasqualotto A.C., de Quadros M., Prezzi S.H. Deficiency of the eighth component of complement associated with recurrent meningococcal meningitis—case report and literature review. Braz J Infect Dis. 2004;8(August (4)):328–330.
Get Medical Pearls directly to your inbox every week!
Weekly posts with high yield medical knowledge, directly to your mailbox!
Dr. C Humphreys

Internal Medicine

Recent Posts

Mechanism of a Mixed Apnea

Mixed apneas are characterized by absent respiratory effort and airflow in the first section of…

2 months ago

How Does Hypothyroidism Cause Hypoventilation?

Although rare, the differential diagnosis of hypoventilation and hypercapnia respiratory failure includes hypothyroidism. It is…

2 months ago

Why is Pro-BNP/ BNP lower in Obesity?

B-type natriuretic peptide (BNP) is a hormone created in response to cardiac wall stretch due…

8 months ago

What is Peribronchovascular Distribution on CT imaging?

A common finding described on computed tomography (CT) imaging. A disease with a peribronchovascular distribution…

1 year ago

Trapped Lung vs. Lung Entrapment

Though often used synonymously; Trapped Lung and Lung Entrapment technically describe separate entities along the…

2 years ago

Cause of Pericardial Effusion in Pulmonary Hypertension: Pathogenesis

It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…

2 years ago

This website uses cookies.