Type 1: Heparin directly causes platelets to aggregate (non-immune). Occurs within 48hrs after initiating heparin; mild, transient and no treatment needed.
Type 2: Heparin induces auto-immune mediated response (antibodies formed against heparin bound to platelet factor 4 (PF4). Characterized by the 4T score. (If the score is 0-3, HIT is unlikely, <5%)
NOTE: HIT is generally not marked by bleeding; instead an increased risk of venous thromboembolism!
REFERENCES
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