Categories: Gastrointestinal

Crohn’s disease and Nephrolithiasis: Mechanism

Renal disorders, especially nephrolithiasis, are observed in one-third of patients with Crohn’s disease, probably related to increased oxalate absorption associated with steatorrhea.

HOW? Inflammation or resection affecting the terminal ileum may result in malabsorption of bile acids — this will inevitably affect fat absorption.

Increased intestinal fat binds dietary calcium, which is then unavailable to bind oxalate (a type of salt). Oxalate is free to be absorbed in the GI tract -> Blood stream -> re-deposited in the kidney (hyperoxaluria), where it can form calcium oxalate stones.

REFERENCES

  1. Cury DB, Moss AC, Schor N. Nephrolithiasis in patients with inflammatory bowel disease in the community. International Journal of Nephrology and Renovascular Disease. 2013;6:139-142. doi:10.2147/IJNRD.S45466.
  2. Ch 13: Gastrointestinal Disease. Pathophysiology of Disease: An Introduction to Clinical Medicine, 7e. Jason C. Mills, MD, PhD, AGAF; Thaddeus S. Stappenbeck, MD, PhD
Get Medical Pearls directly to your inbox every week!
Weekly posts with high yield medical knowledge, directly to your mailbox!
Dr. C Humphreys

Internal Medicine

Recent Posts

Cause of Pericardial Effusion in Pulmonary Hypertension: Pathogenesis

It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…

7 days ago

Difference between Mycophenolate Mofetil vs. Mycophenolate Sodium

The two drugs are not interchangeable nor dose equivalents. Mycophenolate mofetil (Cellcept) is a semi…

3 weeks ago

What is an “Anephric” Creatinine Rise?

Serum Creatinine can be a deceptive surrogate during an acute kidney injury. It may lag…

10 months ago

Macrophage activation syndrome vs. Hemophagocytic lymphohistiocytosis

Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic diseases (i.e SLE, Juvenile idiopathic…

1 year ago

When does a Tracheostomy mature?

After creation of a percutaneous tracheotomy site for prolonged ventilation, one of the immediate complications…

1 year ago

JAMA: Does this patient have Heart Failure? Likelihood Ratios

Two systematic reviews have assessed the diagnostic accuracy of elements of the medical history, physical…

1 year ago

This website uses cookies.