The two drugs are not interchangeable nor dose equivalents.
Mycophenolate mofetil (Cellcept) is a semi synthetic prodrug that is rapidly hydrolyzed in vivo to form the active metabolite, mycophenolic acid (MPA).
Mycophenolate sodium (Myfortic) is an enteric-coated formulation which allows delayed release of MPA into the small intestine.
Myfortic causes less diarrhea, indigestion, and abdominal compared to CellCept.
Manger B, Hiepe F, Schneider M, et al. Impact of switching from mycophenolate mofetil to enteric-coated mycophenolate sodium on gastrointestinal side effects in patients with autoimmune disease: a Phase III, open-label, single-arm, multicenter study. Clin Exp Gastroenterol. 2015;8:205-213. Published 2015 Jul 21. doi:10.2147/CEG.S81922
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