Sulfonylureas were discovered in 1942, and several have been available since the 1960s. Glyburide is a second-generation sulfonylurea, it works by increasing plasma insulin concentrations.
WHY THE RISK OF HYPOGLYCEMIA?
The biological effect of sulfonylureas often lasts much longer than their plasma half-life, because of receptor interaction and formation of active metabolites, persisting 24 h or more. Moreover, their half-life is prolonged in the presence of renal failure.
REFERENCES
Older age is recognized as a risk factor for obstructive sleep apnea.[1] But why? Suspected…
Being overweight (BMI ≥ 25 kg/m2)/Obese (BMI ≥ 30 kg/m2) is one of the most…
Nocturia is a common symptom associated with obstructive sleep apnea. [1] Img Cred: Am J…
ASD (Atrial Septal Defect) Wide, Fixed split S2 (in contrast to the normal variation in…
Mixed apneas are characterized by absent respiratory effort and airflow in the first section of…
Although rare, the differential diagnosis of hypoventilation and hypercapnia respiratory failure includes hypothyroidism. It is…
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