Categories: Endocrinology

How does pH affect Calcium?

Ionized Calcium (Ca2+) and Hydrogen ions (H+) compete for binding to Albumin (-) and other negatively charged protein molecules.

WHEN pH is low (acidosis)

  • Increase in Hydrogen (H+) molecules and therefore less protein binding of Ca2+, INCREASES serum Ca2+ levels.

WHEN pH is high (alkalosis)

  • Decrease in Hydrogen (H+) molecules and therefore more protein binding of Ca2+, DECREASES serum Ca2+ levels.

REFERENCES

  1. Nakamaru Y, Schwartz A. The Influence of Hydrogen Ion Concentration on Calcium Binding and Release by Skeletal Muscle Sarcoplasmic Reticulum. The Journal of General Physiology. 1972;59(1):22-32.
  2. Cooper MS, Gittoes NJL. Diagnosis and management of hypocalcaemia. BMJ : British Medical Journal. 2008;336(7656):1298-1302. doi:10.1136/bmj.39582.589433.BE.
  3. Bushinsky DA, Monk RD. Electrolyte quintet: calcium. Lancet 1998;352:306-11
Get Medical Pearls directly to your inbox every week!
Weekly posts with high yield medical knowledge, directly to your mailbox!
Dr. C Humphreys

Internal Medicine

Recent Posts

Mechanism of a Mixed Apnea

Mixed apneas are characterized by absent respiratory effort and airflow in the first section of…

2 months ago

How Does Hypothyroidism Cause Hypoventilation?

Although rare, the differential diagnosis of hypoventilation and hypercapnia respiratory failure includes hypothyroidism. It is…

2 months ago

Why is Pro-BNP/ BNP lower in Obesity?

B-type natriuretic peptide (BNP) is a hormone created in response to cardiac wall stretch due…

8 months ago

What is Peribronchovascular Distribution on CT imaging?

A common finding described on computed tomography (CT) imaging. A disease with a peribronchovascular distribution…

1 year ago

Trapped Lung vs. Lung Entrapment

Though often used synonymously; Trapped Lung and Lung Entrapment technically describe separate entities along the…

2 years ago

Cause of Pericardial Effusion in Pulmonary Hypertension: Pathogenesis

It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…

2 years ago

This website uses cookies.