Both are minimally absorbed oral antibiotics with broad-spectrum coverage for gram-positive and gram-negative aerobes and anaerobes. They can reduce or eliminate ammonia-producing bacteria as well as blood and brain ammonia levels.
NOTE: long term Neomycin use can lead to renal, auditory, and neurological toxicities, as well as antibiotic-induced microfloral resistances.
*Hence Rifaximin is the agent of choice for long term use. Far fewer complications, with a very low risk of inducing bacterial resistance.
References
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