Within the collecting duct of the kidney, Aquaporin water channels (AQP2) under the regulation of anti diuretic hormone (ADH) control the movement of water into principal cells.
Principal cells: Manage the Na+/K+ exchange in the collecting duct.
Long term lithium ingestion can manifest with polyuria/ polydipisa due to ADH resistance.
HOW?
The proposed thought is principal cells uptake Lithium (cation) via the epithelial sodium channels (ENac) located on the luminal side of the principal cells.
The lithium accumulates in the principal cells, interfering with the ability of ADH to increase water permeability.
REFERENCES
The two drugs are not interchangeable nor dose equivalents. Mycophenolate mofetil is a semi synthetic…
Serum Creatinine can be a deceptive surrogate during an acute kidney injury. It may lag…
Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic diseases (i.e SLE, Juvenile idiopathic…
After creation of a percutaneous tracheotomy site for prolonged ventilation, one of the immediate complications…
Two systematic reviews have assessed the diagnostic accuracy of elements of the medical history, physical…
SYMPTOMS THAT RULE OUT (Lowest -LR): The absence of pain of sudden onset substantively decreases…
This website uses cookies.