Paget’s Disease and High-output Cardiac Heart Failure
Paget’s disease of the bone (accelerated bone turnover and remodeling, resulting in impaired bone integrity and overgrowth) is one of the rare causes of high-output cardiac heart failure.
WHY? It causes extensive hyper vascularization of the bone marrow. This can cause arteriovenous shunting and lower peripheral vascular resistance. Significant bone involvement (>15%) may lead to heart failure.
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