Post hypercapnic alkalosis (PHA) is frequently overlooked as a complication of acutely intubated & mechanically ventilated patients with COPD exacerbations.
HOW DOES IT WORK?
Post hypercapnic alkalosis refers to patients who are hypercapnic (chronic CO2 retainers) and develop a compensatory metabolic alkalosis due to renal bicarbonate (HCO3) retention. After they are intubated, their Pco2 is corrected rapidly, however their chronically elevated bicarbonate remains. This generates a metabolic alkalosis that is typically slow to fall.
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