Refeeding Syndrome is a set of clinical complications that typically occur in severely malnourished patients as a result of aggressive fluid and electrolyte shifts during oral, enteral, or parenteral nourishment.
What conditions put you at risk for Refeeding Syndrome?
What are the clinical manifestations of Refeeding Syndrome?
Prolonged malnourishment leads to decreased carbohydrate intake which reduces serum glucose and ultimately a decreased insulin secretion. As a result, energy supply to the tissues and organs of the body is maintained through lipolysis and protein catabolism which causes intracellular losses of electrolytes, particularly phosphate.
When glucose is re-introduced into the malnourished patient, insulin secretion goes up, and rapidly drives phosphate into cells (including potassium) causing a decrease in the serum concentration of these electrolytes.
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