Uncomplicated Vs. Complicated Staph Aureus Bacteremia

Uncomplicated Staph Aureus Bacteremia 

• No evidence of endocarditis
• No prosthetic device
• No evidence of metastatic infection
• Defervescence after 72 hours of active antibiotic treatment
• Negative blood cultures at 48-96 hours
• Antibiotics for 14 days

Complicated Staph Aureus Bacteremia

• Endocarditis
• Prosthetic device (i.e. pacemaker, prosthetic joint, hemodialysis line)
• Evidence of metastatic infection (abscess, vertebral osteomyelitis, etc.)
• Persistent bacteremia, despite 3 or more days of antibiotic treatment
• Antibiotics for 4-6 weeks

Treatment options for Staph Aureus: 

• Vancomycin, if intolerant: Daptomycin +/- Cloxacillin
• If MSSA, can use Cloxacillin
• If MRSA, use Vancomycin

REFERENCES

Jr, V. G. (2003, September 22). Clinical Identifiers of Complicated Staphylococcus aureus Bacteremia. Retrieved from https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/216060