Categories: Respirology/ ICU

What are Non caseating (Non-necrotizing) Granulomas?

A granuloma is a focal, compact collection of inflammatory cells (i.e histocytes).

Caseation” (translation “turning to cheese”). Non caseating aka Non-necrotizing granulomas do not have characteristic necrotic appearance on gross visual examination and generally are of non-infectious etiology. More info here.

  • Seen in conditions such as: ***Sarcoidosis***, hypersensitivity pneumonitis, IBD and chronic Beryllium disease

REFERENCES

  1. James DG (1991). What makes granulomas tick? Thorax 46: 734736.
  2. Iannuzzi M, Rybicki BA, Teirstein AS (2007). “Sarcoidosis”. New England Journal of Medicine 357 (21): 2153–2165.
  3. Zumla A, James DG (1996). Granulomatous infections: etiology and classification. Clin Infect Dis 23:146–158
  4. Chapter 390: Sarcoidosis. Harrison’s Principles of Internal Medicine, 19e. Robert P. Baughman; Elyse E. Lower
Get Medical Pearls directly to your inbox every week!
Weekly posts with high yield medical knowledge, directly to your mailbox!
Dr. C Humphreys

Internal Medicine

Recent Posts

Mechanism of a Mixed Apnea

Mixed apneas are characterized by absent respiratory effort and airflow in the first section of…

12 months ago

How Does Hypothyroidism Cause Hypoventilation?

Although rare, the differential diagnosis of hypoventilation and hypercapnia respiratory failure includes hypothyroidism. It is…

12 months ago

Why is Pro-BNP/ BNP lower in Obesity?

B-type natriuretic peptide (BNP) is a hormone created in response to cardiac wall stretch due…

1 year ago

What is Peribronchovascular Distribution on CT imaging?

A common finding described on computed tomography (CT) imaging. A disease with a peribronchovascular distribution…

2 years ago

Trapped Lung vs. Lung Entrapment

Though often used synonymously; Trapped Lung and Lung Entrapment technically describe separate entities along the…

3 years ago

Cause of Pericardial Effusion in Pulmonary Hypertension: Pathogenesis

It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…

3 years ago

This website uses cookies.