Hypercalcemia affects up to a third of cancer patients and malignant hypercalcemia is the most common oncological emergency leading to hospitalization.
Most likely to occur in: breast cancer, multiple myeloma and lung cancer. However, it can also be found in other malignancies, including: gynecologic, renal and head & neck cancers
CAUSE: Increased osteoclastic bone resorption.
Solid tumours can produce parathyroid hormone–related protein (PTHrP), increasing calcium levels in the blood by activating parathyroid hormone receptors in tissue, which results in osteoclastic bone resorption; it also increases renal tubular resorption of calcium.
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