B-type natriuretic peptide (BNP) is a hormone created in response to cardiac wall stretch due to volume or pressure overload. Its precursor molecule is proBNP.
BNP is noted to have numerous effects on different target organs, including:
-Dilatation of afferent renal arterioles while constricting of efferent renal arterioles -> increasing renal filtration to promote diuresis.
-Stimulation of lipolysis.
-Increased insulin secretion.
Why is it lower in obese patients who may be clinically in heart failure?
Thought to be multi-factorial. Mainly driven by upregulation of receptor: NPR-C (driven by increases in proinflammatory IL-6 by adipose tissue) and ubiquitous endopeptidase, Nephrlysin (NEP), resulting in increased degradation and clearance of BNP.
REFERENCES:
Obstructive sleep apnea (OSA) is thought to lead to secondary polycythemia due to intermittent hypoxia,…
Catabolism of hemoglobin leads to the release of heme, which converts to biliverdin and then…
Tongue scalloping refers to the series of indentations along the sides of the tongue that…
Older age is recognized as a risk factor for obstructive sleep apnea.[1] But why? Suspected…
Being overweight (BMI ≥ 25 kg/m2)/Obese (BMI ≥ 30 kg/m2) is one of the most…
Nocturia is a common symptom associated with obstructive sleep apnea. [1] Img Cred: Am J…
This website uses cookies.