Wolff-Chaikoff Effect: Iodine induced hypothyroidism. Can occur in normal or hyperthyroid state. Can be used as treatment against hyperthyroidism (i.e thyroid storm); Excess iodide transiently inhibits thyroid iodide organification. In individuals with normal thyroid function, they will undergo the escape phenomena (the gland escapes from this inhibitory effect and iodide organification resumes) after several days.
Jod-Basedow Phenomenon: Iodine induced hyperthyroidism. In individuals with iodine deficient hypothyroidism, thyroid hormone synthesis becomes excessive as a result of increased iodine exposure. NOTE: this does not occur in euthyroid individuals!
REFERENCES
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