Sulfonylureas were discovered in 1942, and several have been available since the 1960s. Glyburide is a second-generation sulfonylurea, it works by increasing plasma insulin concentrations.
WHY THE RISK OF HYPOGLYCEMIA?
The biological effect of sulfonylureas often lasts much longer than their plasma half-life, because of receptor interaction and formation of active metabolites, persisting 24 h or more. Moreover, their half-life is prolonged in the presence of renal failure.
- Feldman JM. Glyburide: a second-generation sulfonylurea hypoglycemic agent. History, chemistry, metabolism, pharmacokinetics, clinical use and adverse effects. Pharmacotherapy. 1985 Mar-Apr;5(2):43-62.
Sola D, Rossi L, Schianca GPC, et al. Sulfonylureas and their use in clinical practice. Archives of Medical Science : AMS. 2015;11(4):840-848. doi:10.5114/aoms.2015.53304.