Entresto is made up of two molecules => Valsartan & Scubitril

  • Valsartan is an ARB (Angiotensin receptor blockers) =>  Angiotensin II AT1 receptor blocker
  • Scubitril => Neprilysin inhibitor
Valsartan-sacubitril-Entresto-Mechanism
Img Credit: Vardeny O, Miller R, Solomon SD

REFERENCES

  1. McMurray JJ, Packer M, Desai AS, et al. Angiotensin-neprilysin inhibition versus enalapril in heart failure. N Engl J Med 2014;371:993-1004
  2. Vardeny O, Miller R, Solomon SD. Combined Neprilysin and Renin-Angiotensin System Inhibition for the Treatment of Heart Failure. JCHF. 2014;2(6):663-670. doi:10.1016/j.jchf.2014.09.001

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