Categories: Neurology

Why does Albuminocytologic Dissociation occur?

Characteristic finding in Guillain–Barré syndrome (also associated with spinal block and with intracranial neoplasia)

  • Elevated protein level (albumin) in CSF
  • Low numbers of white blood cells in CSF

Why? Altered blood-nerve-CSF barrier and leaky spinal root capillaries (due to inflammation) => Albumin moves into the Subarachnoid space (CSF). WBCs remain the nerve roots; demyelinating. Hence the raised protein concentration without pleocytosis. [1]


  1. Hughes RA, Rees JH. Clinical and epidemiological features of Guillain-Barré syndrome. J Infect Dis. 1997;176:S92–8. [PubMed]
Get Medical Pearls directly to your inbox every week!
Weekly posts with high yield medical knowledge, directly to your mailbox!
Dr. C Humphreys

Internal Medicine

Recent Posts

Mechanism of a Mixed Apnea

Mixed apneas are characterized by absent respiratory effort and airflow in the first section of…

6 months ago

How Does Hypothyroidism Cause Hypoventilation?

Although rare, the differential diagnosis of hypoventilation and hypercapnia respiratory failure includes hypothyroidism. It is…

6 months ago

Why is Pro-BNP/ BNP lower in Obesity?

B-type natriuretic peptide (BNP) is a hormone created in response to cardiac wall stretch due…

1 year ago

What is Peribronchovascular Distribution on CT imaging?

A common finding described on computed tomography (CT) imaging. A disease with a peribronchovascular distribution…

2 years ago

Trapped Lung vs. Lung Entrapment

Though often used synonymously; Trapped Lung and Lung Entrapment technically describe separate entities along the…

2 years ago

Cause of Pericardial Effusion in Pulmonary Hypertension: Pathogenesis

It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…

2 years ago

This website uses cookies.