Categories: Neurology

Why does Albuminocytologic Dissociation occur?

Characteristic finding in Guillain–Barré syndrome (also associated with spinal block and with intracranial neoplasia)

  • Elevated protein level (albumin) in CSF
  • Low numbers of white blood cells in CSF

Why? Altered blood-nerve-CSF barrier and leaky spinal root capillaries (due to inflammation) => Albumin moves into the Subarachnoid space (CSF). WBCs remain the nerve roots; demyelinating. Hence the raised protein concentration without pleocytosis. [1]


  1. Hughes RA, Rees JH. Clinical and epidemiological features of Guillain-Barré syndrome. J Infect Dis. 1997;176:S92–8. [PubMed]
Get Medical Pearls directly to your inbox every week!
Weekly posts with high yield medical knowledge, directly to your mailbox!
Dr. C Humphreys

Internal Medicine

Recent Posts

Mechanism of a Mixed Apnea

Mixed apneas are characterized by absent respiratory effort and airflow in the first section of…

12 months ago

How Does Hypothyroidism Cause Hypoventilation?

Although rare, the differential diagnosis of hypoventilation and hypercapnia respiratory failure includes hypothyroidism. It is…

12 months ago

Why is Pro-BNP/ BNP lower in Obesity?

B-type natriuretic peptide (BNP) is a hormone created in response to cardiac wall stretch due…

1 year ago

What is Peribronchovascular Distribution on CT imaging?

A common finding described on computed tomography (CT) imaging. A disease with a peribronchovascular distribution…

2 years ago

Trapped Lung vs. Lung Entrapment

Though often used synonymously; Trapped Lung and Lung Entrapment technically describe separate entities along the…

3 years ago

Cause of Pericardial Effusion in Pulmonary Hypertension: Pathogenesis

It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…

3 years ago

This website uses cookies.