Studies have demonstrated that patients with pneumococcal meningitis had reduced mortality (14 versus 34 percent placebo) and hearing loss (ototoxicity) when dexamethasone was given shortly before (~20mins) or concurrently with first dose antimicrobial therapy.
Dosed: Dexa 10mg IV 20mins prior or same time before first dose q6hrs x4 days.
NOTE: Patients who did not have pneumococcal meningitis (i.e meningococcal meningitis) had significantly lower rates of mortality (4 vs. 9 percent placebo), regardless of dexamethasone therapy. Also, patients are unlikely to benefit from steroids if they are started AFTER initiation of antimicrobial therapy.
REFERENCES
Though often used synonymously; Trapped Lung and Lung Entrapment technically describe separate entities along the…
It is not clearly understood why patients with pulmonary hypertension (PH) develop pericardial effusions. However,…
The two drugs are not interchangeable nor dose equivalents. Mycophenolate mofetil (Cellcept) is a semi…
Serum Creatinine can be a deceptive surrogate during an acute kidney injury. It may lag…
Macrophage activation syndrome (MAS) is a life-threatening complication of rheumatic diseases (i.e SLE, Juvenile idiopathic…
After creation of a percutaneous tracheotomy site for prolonged ventilation, one of the immediate complications…
This website uses cookies.