Paradoxical breathing (abdominal paradox): Mechanism

7 years ago

During a Respiratory exam, the question of paradoxical breathing commonly comes up. The more accurate and correct term is actually…

PFTs: What is pseudorestriction?

7 years ago

Sometimes when interpreting spiromtery, a patient may have what appears to be a mixed obstructive/ restrictive picture. (Reduced FEV1/FVC and…

Lithium and Nephrogenic Diabetes Insipidus: Mechanism

7 years ago

Within the collecting duct of the kidney, Aquaporin water channels (AQP2) under the regulation of anti diuretic hormone (ADH) control the…

Trimethoprim/sulfamethoxazole and increased Creatinine: Mechanism

7 years ago

The serum creatinine concentration (Cr) is typically used as a surrogate for renal function. Hence, when increased it is often…

Urea: Ineffective Osmole

7 years ago

Plasma Osmolality: The total solute concentration within a given fluid compartment (Mosm/kg). Hence it is NOT dependent on temperature and…

How does CHF cause AKI?

7 years ago

It is quite common to see accompanying acute kidney injury during a congestive heart failure exacerbation.  WHY? Renal hypo-perfusion secondary…

Carcinoid syndrome: Mechanism of action

7 years ago

Carcinoid tumors are rare neuroendocrine tumors which originate most often in the bowel, less commonly in the lungs, and rarely…

Hypokalemia Treatment and Dextrose

7 years ago

A common treatment modality for hypokalemia is intravenous potassium replacement; especially in the setting of critically low values (<2.5). When…

Hunger Bone Syndrome: Mechanism

7 years ago

Hungry Bone syndrome is a phenomenon of post-operative hypocalcemia. It is an uncommon, but serious post-surgical sequalae of parathyroidectomy. It…

Glyburide and Hypogylcemia

7 years ago

Sulfonylureas were discovered in 1942, and several have been available since the 1960s. Glyburide is a second-generation sulfonylurea, it works…

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