Drugs/Metabolism

Pregablin (Lyrica) vs Gabapentin (Neurontin)

SIMILARITIES Both medications are often used to treat neuropathic pain and epilepsy Mechanism: Both work via inhibition of Ca+ influx and…

9 years ago

Why do Calcium channel blockers cause Edema?

MECHANISM: Decrease in arteriolar resistance via vasodilation. This arterial vasodilation goes unmatched by the venous circulation, which CCB do not…

10 years ago

Nondihydropyridine vs. Dihydropyridine Calcium Channel Blockers

Dihydropyridine: Think Amlodipine and Nifedipine (-dipine) They act through systemic vascular vasodilation of arteries. Can be used to treat angina.…

10 years ago

What Antibiotics interfere with OCP?

Rifampin is the antibiotic that is classically stated to be avoided in women taking OCPs HOW? Rifampin is a potent…

10 years ago

Why avoid Alcohol with Metronidazole (Flagyl)?

It is often stated to patients and even on the product monograph to avoid the use of alcohol when taking…

10 years ago

How does Allopurinol work?

Allopurinol => enzyme xanthine oxidase inhibitor Therefore blocks the conversion of the purine metabolites (hypoxanthine and xanthine) into uric acid.…

10 years ago

Why & How to Monitor Vancomycin Troughs?

Vancomycin is a glycopeptide antibiotic, typically used for treatment of MRSA. Traditionally it is recommended to get trough doses to…

10 years ago

Why do NSAIDs cause Peptic ulcers?

non-steroidal anti-inflammatory drugs (NSAIDs) irritate gastroduodenal mucosa, suppress prostaglandin production, impair the ability of the mucosa to repair (reduction in…

10 years ago

How Rifaximin/ Neomycin treats Hepatic Encephalopathy?

Both are minimally absorbed oral antibiotics with broad-spectrum coverage for gram-positive and gram-negative aerobes and anaerobes. They can reduce or…

10 years ago

How Lactulose treats Hepatic Encephalopathy?

Lactulose (want to achieve 2-3 soft bowel movements per day) Lactulose prevents ammonia (NH3) from diffusing out of the colon…

10 years ago

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