Drugs/Metabolism

Pregablin (Lyrica) vs Gabapentin (Neurontin)

SIMILARITIES Both medications are often used to treat neuropathic pain and epilepsy Mechanism: Both work via inhibition of Ca+ influx and…

5 years ago

Why do Calcium channel blockers cause Edema?

MECHANISM: Decrease in arteriolar resistance via vasodilation. This arterial vasodilation goes unmatched by the venous circulation, which CCB do not…

5 years ago

Nondihydropyridine vs. Dihydropyridine Calcium Channel Blockers

Dihydropyridine: Think Amlodipine and Nifedipine (-dipine) They act through systemic vascular vasodilation of arteries. Can be used to treat angina.…

5 years ago

What Antibiotics interfere with OCP?

Rifampin is the antibiotic that is classically stated to be avoided in women taking OCPs HOW? Rifampin is a potent…

5 years ago

Why avoid Alcohol with Metronidazole (Flagyl)?

It is often stated to patients and even on the product monograph to avoid the use of alcohol when taking…

5 years ago

How does Allopurinol work?

Allopurinol => enzyme xanthine oxidase inhibitor Therefore blocks the conversion of the purine metabolites (hypoxanthine and xanthine) into uric acid.…

5 years ago

Why monitor Vancomycin troughs?

Vancomycin is a glycopeptide antibiotic, typically used for treatment of MRSA. Traditionally it is recommended to get trough doses to…

5 years ago

Why do NSAIDs cause Peptic ulcers?

non-steroidal anti-inflammatory drugs (NSAIDs) irritate gastroduodenal mucosa, suppress prostaglandin production, impair the ability of the mucosa to repair (reduction in…

5 years ago

How Rifaximin/ Neomycin treats Hepatic Encephalopathy?

Both are minimally absorbed oral antibiotics with broad-spectrum coverage for gram-positive and gram-negative aerobes and anaerobes. They can reduce or…

5 years ago

How Lactulose treats Hepatic Encephalopathy?

Lactulose (want to achieve 2-3 soft bowel movements per day) Lactulose prevents ammonia (NH3) from diffusing out of the colon…

5 years ago

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