Endocrinology

Why does Dumping Syndrome cause Hypoglycemia?

The stomach acts as a reservoir for digestion. Food will be stored and broken down in it via acid and…

10 years ago

Why does Iron Poisoning cause Metabolic Acidosis?

Iron poisoning is often listed in the classic metabolic acidosis mnemonic MUDPILES, but how does it cause an anion gap…

10 years ago

Diastolic Hypertension in Hypothyroidism: Mechanism

Hypothyroidism has been recognized as a cause of secondary hypertension. Img Cred: http://circ.ahajournals.org/ Previous studies on the prevalence of hypertension…

10 years ago

Hyperparathyroidism: Primary, Secondary, Tertiary

Primary: Elevated PTH that results in elevated Ca2+. Typically caused by parathyroid adenoma.  Secondary: Elevated PTH due to Low Ca2+ (Hypocalcemia).…

10 years ago

How does pH affect Calcium?

Ionized Calcium (Ca2+) and Hydrogen ions (H+) compete for binding to Albumin (-) and other negatively charged protein molecules. WHEN…

10 years ago

Thyroxine-binding Globulin (TBG) and Pregnancy

During the first 20 weeks of pregnancy, serum TBG levels will increase by two fold. This causes more T3/T4 to…

10 years ago

Why is Sodium (Na+) times two in Osmolar gap?

The serum osmolality is calculated by the concentrations of the different effective osmoles which compose it. The formula: Calculated Sosm  …

10 years ago

Dawn phenomenon vs. Somogyi effect

Both will result in AM (morning) hyperglycemia. DAWN: "Think Dawn is Down" => Early morning hypergylcemia without preceding hypogylcemia. Secondary…

10 years ago

Hyperprolactinemia and Hypothyroidism: Mechanism

Hyperprolactinemia is one of the most common endocrine disorders in the hypothalamic- pituitary axis. Although the most common etiologies of…

10 years ago

Wolff-Chaikoff Effect vs. Jod-Basedow Phenomenon

Wolff-Chaikoff Effect: Iodine induced hypothyroidism. Can occur in normal or hyperthyroid state. Can be used as treatment against hyperthyroidism (i.e…

10 years ago

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