Why does Iron Poisoning cause Metabolic Acidosis?

10 years ago

Iron poisoning is often listed in the classic metabolic acidosis mnemonic MUDPILES, but how does it cause an anion gap…

MGUS vs. Multiple Myeloma vs. Waldenstrom’s

10 years ago

Monoclonal gammopathy of undetermined significance (MGUS) Asymptomatic premalignant state Common in elderly population (~10% in patients >75 years old) Paraprotein…

pRBCs: Hypotonic solution vs. Ringer Lactate

10 years ago

Do not mix pRBC infusion with hypotonic solution (i.e D5W). Why? The hypotonic solution has a lower osmolarity, will shift…

Heparin-Induced Thrombocytopenia (HIT): Type 1 vs. Type 2

10 years ago

Type 1: Heparin directly causes platelets to aggregate (non-immune). Occurs within 48hrs after initiating heparin; mild, transient and no treatment…

C5-C9 Deficiency: Neisseria infections

10 years ago

Neisseria meningitidis (Gram-negative cocci) life threatening cause of sepsis and bacterial meningitis. Classically, individuals who lack terminal complement proteins (C5-C9)…

Caloric Reflex (COWS): How does it work?

10 years ago

The Caloric Reflex Test is used to test the Vestibulo–ocular reflex. It is one of the tests used to assess…

Triad of Wernicke’s Encephalopathy

10 years ago

Classical clinical symptoms of Wernicke's Encephalopathy: Encephalopathy (i.e disorientation, inattentiveness) Oculomotor dysfunction (i.e typically bilateral horizontal nystagmus, lateral rectus palsy)…

Triad of Lewy Body Dementia

10 years ago

Classical clinical symptoms of Lewy Body Dementia (LBD) include: Fluctuating level of cognitive impairment Recurring visual hallucinations Parkinsonism (i.e bradykinesia,…

Diastolic Hypertension in Hypothyroidism: Mechanism

10 years ago

Hypothyroidism has been recognized as a cause of secondary hypertension. Img Cred: http://circ.ahajournals.org/ Previous studies on the prevalence of hypertension…

Hyperparathyroidism: Primary, Secondary, Tertiary

10 years ago

Primary: Elevated PTH that results in elevated Ca2+. Typically caused by parathyroid adenoma.  Secondary: Elevated PTH due to Low Ca2+ (Hypocalcemia).…

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